What is Radiesse®? Radiesse® is an FDA-approved dermal filler formulated with calcium hydroxylapatite microspheres. This unique composition makes Radiesse® a safe and effective treatment option for both women and men looking to reverse the signs of aging in their face, neck, body and hands. When injected into the skin, Radiesse® replenishes lost volume and stimulates the production of collagen, a vital protein responsible for maintaining skin elasticity and firmness.